Letwell
(Letrozole IP 2.5 mg tablets)A well accepted aromatase inhibitor...
Letrozole an aromatase inhibitor blocks the conversion of androgens to estrogens in the ovarian follicles,peripheral tissues and in the brain.this result in to 2 things a) a fall in circulating and local estrogens.b)rise in intra ovarian androgens.
Fall in estrogen levels releases the hypothalamo pituitary axis from the negative feedback of estrogens.thus there is a surge in follicle stimulating hormone (FSH) release which results in follicular growth.since the feedback mechanism is intact normal follicular growth,selection of dominant follicle and atresia of smaller growing follicles occurs and there by facilitating mono follicular growth and ovulation.
Another mechanism of action is increasing intra ovarian androgen in early follicular development augment FSH receptors and stimulating insulin like growth factor IGF-1 and FSH act synergistically to promote follicular growth....
For more details consult your Physician
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